The usual dose for acute diarrhoea in an adult is four tablets initially, followed by two tablets every six hours until symptoms are controlled, not exceeding 10 tablets in 24 hours.
Co-phenotrope, also known as Lomotil, combines diphenoxylate hydrochloride and atropine sulfate to treat acute diarrhoea effectively. When experiencing diarrhoea, maintain hydration by drinking plenty of fluids to avoid dehydration, and resume normal eating as tolerated. Consult a doctor if symptoms persist beyond 48 hours. This medication is not for children under 16 without medical supervision.
About co-phenotrope
| Type of medicine | An antimotility medicine |
|---|---|
| Used for | Diarrhoea |
| Also called | Diphenoxylate hydrochloride with atropine sulfate |
| Available as | Tablets |
Co-phenotrope addresses acute diarrhoea, which onset suddenly and resolves within two weeks. It features two active ingredients: diphenoxylate hydrochloride, the primary agent slowing bowel motility, and atropine sulfate, added to deter overuse due to its unpleasant effects at high doses. Common triggers include infections, excessive alcohol like beer, medication side effects, or anxiety, with most cases self-limiting in days. Primary management focuses on rehydration; co-phenotrope aids by reducing toilet visits.
Diphenoxylate, an opioid-like compound, activates mu receptors in the gastrointestinal tract, decreasing peristalsis and prolonging transit time for better water absorption and firmer stools. This segmentation enhances mucosal contact, alleviating symptoms. Post-intestinal surgery, it regulates bowel function. Diarrhoea typically halts within 48 hours; extended use risks dependency.
Before taking co-phenotrope
Review the patient information leaflet for comprehensive details on usage and side effects. Inform your doctor of:
- Liver or kidney impairment
- Respiratory conditions like asthma or COPD
- Prostate issues or urinary difficulties
- Low blood pressure
- Thyroid or adrenal disorders
- Epilepsy
- Bile duct obstruction
- Bowel obstruction or inflammatory conditions
- Myasthenia gravis
- History of drug addiction
- Allergies to medications
- Concurrent medications, including over-the-counter and herbal remedies
Co-phenotrope is prescription-only, habit-forming if overdosed due to diphenoxylate’s narcotic relation; atropine counters misuse. Not suitable for children under 16 without prescription. Pregnant or breastfeeding individuals should consult professionals.
How to take co-phenotrope
Adults start with four tablets, then two every six hours as needed, max 10 daily (equivalent to 20mg diphenoxylate and 0.2mg atropine). Tablets can be taken with food; space doses evenly. Symptoms often improve in 48 hours; if not, or worsening within 10 days, seek medical advice. Reduce dose once controlled.
Dosage Table for Adults (Acute Diarrhoea):
| Initial Dose | Maintenance Dose | Maximum Daily |
|---|---|---|
| 4 tablets (10 mg diphenoxylate) | 2 tablets every 6 hours | 10 tablets (20 mg diphenoxylate) |
Swallow whole with water; do not exceed prescribed amount to avoid atropine toxicity. Regular doctor check-ups monitor efficacy and side effects.
Getting the most from your treatment
Pair with oral rehydration solutions for fluid and electrolyte balance. Eat normally when appetite returns to support recovery. Most need it briefly; discontinue upon relief. If ineffective after 48 hours, consult a doctor. Avoid alcohol, as it may intensify drowsiness or dehydration. Drive or operate machinery only if unaffected.
Can co-phenotrope cause problems?
Common side effects include drowsiness, dizziness, headache, nausea, abdominal discomfort, dry mouth, blurred vision, and constipation.
| Side Effect | Advice |
|---|---|
| Drowsiness, dizziness, tiredness | Avoid driving or machinery until resolved |
| Headache | Hydrate; use pharmacist-recommended painkiller; consult if persistent |
| Abdominal discomfort, nausea | Take with food |
| Constipation | Discontinue use |
| Confusion, restlessness, fever, urinary issues, flushing | Monitor; stop if troublesome |
Serious effects like severe constipation, allergic reactions (rash, swelling, breathing difficulty), or neurological symptoms warrant immediate medical attention. Atropine overdose may cause tachycardia, confusion. Long-term use risks dependence. Report new symptoms to healthcare provider.
How to store co-phenotrope
Store below 25°C in original packaging, away from children and moisture. Do not use post-expiry; dispose responsibly via pharmacy.
Important information about all medicines
Keep medicines inaccessible to children. Understand potential allergies. Note drowsiness may impair activities. Check interactions with other drugs. Report side effects via Yellow Card scheme. For overdose, contact emergency services immediately.
Frequently Asked Questions (FAQs)
Q: How quickly does co-phenotrope work?
A: Relief often begins within hours, with diarrhoea typically stopping in 2 days.
Q: Can children take co-phenotrope?
A: Not recommended under 16 without doctor prescription.
Q: Is co-phenotrope habit-forming?
A: Yes, diphenoxylate can be if misused; atropine prevents abuse.
Q: What if diarrhoea persists?
A: See a doctor after 48 hours or if worsening.
Q: Can I drink alcohol with co-phenotrope?
A: Avoid, as it worsens side effects and dehydration.
Q: Is co-phenotrope available over-the-counter?
A: No, prescription required.
References
- Co-phenotrope tablets for diarrhoea – Lomotil — Patient.info. 2023. https://patient.info/medicine/co-phenotrope-tablets-for-diarrhoea
- Diphenoxylate/atropine — WikiProjectMed – MDWiki.org. 2024. https://mdwiki.org/wiki/Diphenoxylate/atropine
- Diphenoxylate and atropine (oral route) — Mayo Clinic. 2024-10-01. https://www.mayoclinic.org/drugs-supplements/diphenoxylate-and-atropine-oral-route/description/drg-20061751
- Lomotil (Diphenoxylate & Atropine): Uses & Side Effects — Cleveland Clinic. 2024. https://my.clevelandclinic.org/health/drugs/19878-diphenoxylate-atropine-tablets
- Diphenoxylate: Uses, Interactions, Mechanism of Action — DrugBank. 2024. https://go.drugbank.com/drugs/DB01081
